Republican leaders in Congress on Sunday said a potential U.S.-led accord with Iran will let the Islamic Republic continue working on a nuclear weapon, and predicted a tough fight to win legislative approval.

House Speaker John Boehner said President Barack Obama has backed away from guidelines set for the talks, and Senate Majority Leader Mitch McConnell said “a very hard sell” will be needed for a deal worked out by the U.S. and five other countries to pass Congress. Leaders of the Senate Foreign Relations Committee also voiced concern...

Senate Foreign Relations Committee Chairman Bob Corker and the committee’s top Democrat, Robert Menendez of New Jersey, said they are uncomfortable with the course of negotiations.

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